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KMID : 0352720140380010028
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Journal of Ginseng Research
2014 Volume.38 No. 1 p.28 ~ p.33
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New dammarane-type triterpenoids from the leaves of Panax notoginseng and their protein tyrosine phosphatase 1B inhibitory activity
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Li Dawei
Jiaqing Cao
Xiuli Bi
Xichun Xia
Wei Li
Yuqing Zhao
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Abstract
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Background: Panax notoginseng has been used as a general tonic agent to invigorate human body for millennia in China and continued to be used until present. Methods: Some chromatographic methods were performed to isolate pure triterpenoids, and their structures were determined by nuclear magnetic resonance (NMR) experiments. Anti-diabetes activities of isolated compounds were evaluated through their inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) enzyme. Results and Conclusion: Three new dammarane-type triterpenoids, notoginsenoside-LX (1), notoginsenoside-LY (2), and notoginsenoside-FZ (3) together with eighteen known compounds were isolated from the Panax notoginseng leaves. The structure-activity relationship of the compounds with dammaranetype triterpenoids and their PTP1B inhibitory activity were also reported. Results showed that compounds 2, 15, 20, and 21 can significantly inhibit the enzyme activity of PTP1B in a dose-dependent manner, with inhibitory concentration 50 (IC50) values of 29.08 mM, 21.27 mM, 28.12 mM, and 26.59 mM, respectively. The results suggested that Panax notoginseng leaves might have potential as a new therapeutic agent for the treatment of diabetes.
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KEYWORD
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notoginsenoside-FZ, notoginsenoside-LX, notoginsenoside-LY, Panax notoginseng, protein tyrosine phosphatase 1B
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